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PI-loting membrane traffic

Nature Cell Biology volume 6, pages 487–492 (2004)Cite this article

Abstract

Phosphoinositides (PIs) undergo phosphorylation/dephosphorylation cycles through organelle-specific PI kinases and PI phosphatases that lead to distinct subcellular distributions of the individual PI species. Specific PIs control the correct timing and location of many trafficking events. Their ultimate mode of action is not always well defined, but it includes localized recruitment of transport machinery, allosteric regulation of PI-binding proteins and changes in the physical properties of the membrane.

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Figure 1: The phosphorylation/dephosphorylation cycles of PIs.
Figure 2: 'PI-map' of the endocytic and exocytic pathways.

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Acknowledgements

The authors would like to thank C. Berrie for reading the manuscript and E. Fontana for artwork preparation. This work has been supported in part by the Italian Association for Cancer Research, Telethon Italia, European Community and by the Italian Ministry of Education.

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  1. Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, via Nazionale, Santa Maria Imbaro (Chieti), 66030, Italy

    Maria Antonietta De Matteis & Anna Godi

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Correspondence to Maria Antonietta De Matteis.

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Matteis, M., Godi, A. PI-loting membrane traffic. Nat Cell Biol 6, 487–492 (2004). https://doi.org/10.1038/ncb0604-487

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