Telomere shortening resulting from genome replication can trigger cellular senescence. In this issue Clark et al. show that rates of telomere attrition and the consequent replicative potential of cells are conserved during replicative cloning. This implies that these traits are genetically determined and raises interesting questions about their relationship to organismal phenotypes such as cancer, organ failure and ageing.
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References
Wilmut, I. et al. Nature 419, 583–587 (2002).
Brophy, B. et al. Nature Biotechnol. 21, 157–162 (2003).
Rideout, W.M., Eggan, K. & Jaenisch, R. Science 293, 1093–1098 (2001).
Betts, D.H. et al. Proc. Natl Acad. Sci. USA 98, 1077–1082 (2001).
Clark, A.J. et al. Nat. Cell Biol. 5, 535–538 (2003).
Wright, W.E. & Shay, J.W. Nature Biotechnol. 20, 682–688 (2002).
Bodnar, A.G. et al. Science 279, 349–352 (1998).
Shay, J.W. & Wright, W.E. Cancer Cell 2, 257–265 (2002).
Blasco, M.A. Nature Rev. Cancer 2, 1–7 (2002).
Smith, L.L., Coller, H.A. & Roberts, J.M. Nature Cell Biol. 5, 474–479 (2003).
Maser, R.S. & DePinho, R.A. Science 297, 565–569 (2002).
Cristofalo, V.J. et al. Proc. Natl Acad. Sci. USA 95, 10614–10619 (1998).
Baerlocher, G.M. et al. J. Leukocyte Biol. 73, 289–296 (2003).
Campisi, J. Exp. Gerontol. 38, 5–11 (2003).
Burke, A. Biogerontol. 1, 41–46 (2000).
Serra, V., von Zglinicki, T., Lorenz, M. & Saretzki, G. J. Biol. Chem. 278, 6824–6830 (2003).
Mondello, C. et al. Exp. Cell Res. 248, 234–242 (1999).
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Sedivy, J. Reproductive cloning conserves cellular senescence. Nat Cell Biol 5, 495–496 (2003). https://doi.org/10.1038/ncb0603-495
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DOI: https://doi.org/10.1038/ncb0603-495
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