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Memorable transcription

Nature Cell Biology volume 5, pages 390–393 (2003)Cite this article

Experiments in the yeast Saccharomyces cerevisiae have shown that the enzyme Set1 preferentially targets the 5′ coding regions of transcriptionally active genes, where it catalyses di- and tri-methylation of histone H3 Lys 4. This methylation mark is retained after transcription has subsided, suggesting that it provides a memory of recent transcription.

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Figure 1: Enzyme families that modify histone tails on the nucleosome surface.
Figure 2: Localized changes in H3 methylation generated by the transcribing PolII complex.

References

  1. Ng, H.H., Robert, F., Young, R.A. & Struhl, K. Mol. Cell 11, 709–719 (2003).

    Article  CAS  PubMed  Google Scholar 

  2. Krogan, N.J. et al. Mol. Cell 11, 721–729 (2003).

    Article  CAS  PubMed  Google Scholar 

  3. Turner, B.M. Cell 111, 285–291 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Jenuwein, T. & Allis, C.D. Science 293, 1074–1080 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Richards, E.J. & Elgin, S.C.R. Cell 108, 489–500 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Bird, E.W. et al. Nature 419, 411–415 (2002).

    Article  CAS  PubMed  Google Scholar 

  7. Bernstein, B.E. & Schreiber, S.L. Cell 111, 771–778 (2002).

    Article  PubMed  Google Scholar 

  8. Bernstein, B.E. et al. Proc. Natl Acad. Sci. USA 99, 8695–8700 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Santos-Rosa, H. et al. Nature 419, 407–411 (2002).

    Article  CAS  PubMed  Google Scholar 

  10. Zhang, Y. & Reinberg, D. Genes Dev. 15, 2343–2360 (2001).

    Article  CAS  PubMed  Google Scholar 

  11. Van Leeuwen, F., Gafken, P.R. & Gottschling, D.E. Cell 109, 745–756 (2002).

    Article  CAS  PubMed  Google Scholar 

  12. Sun, Z.-W. & Allis, C.D. Nature 418, 104–108 (2002).

    Article  CAS  PubMed  Google Scholar 

  13. Dover et al. J. Biol. Chem. 277, 28368–28371 (2002).

    Article  CAS  PubMed  Google Scholar 

  14. Milne, T.A. et al. Mol. Cell 10, 1107–1117 (2002).

    Article  CAS  PubMed  Google Scholar 

  15. Bryk, M. et al. Curr. Biol. 12, 165–170 (2002).

    Article  CAS  PubMed  Google Scholar 

  16. Ng et al. Genes Dev. 16, 1518–1527 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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  1. Anatomy Department, Chromatin and Gene Expression Group, University of Birmingham Medical School, Birmingham, B15 2TT, United Kingdom

    Bryan M. Turner

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  1. Bryan M. Turner
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Turner, B. Memorable transcription. Nat Cell Biol 5, 390–393 (2003). https://doi.org/10.1038/ncb0503-390

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