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AP-1 as a regulator of cell life and death

Nature Cell Biology volume 4, pages E131E136 (2002) | Download Citation

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Abstract

The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified. Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed.

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Affiliations

  1. Department of Experimental Medicine and Cancer Research, School of Medicine, the Hebrew University, Jerusalem, 91120, Israel eshaulian@md.huji.ac.il

    • Eitan Shaulian
  2. Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA karinoffice@ucsd.edu

    • Michael Karin

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https://doi.org/10.1038/ncb0502-e131