A crucial aspect of cell function in tissues is the biophysical interactions of the cell with the surrounding extracellular matrix. A fascinating report in this issue offers a major advance in the techniques available for investigating how the transmission of cell-generated forces to an underlying substratum is regulated. Application of this approach should provide key insights into such force regulation during cell migration and matrix contraction.
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Lauffenburger, D., Wells, A. Getting a grip: new insights for cell adhesion and traction. Nat Cell Biol 3, E110–E112 (2001). https://doi.org/10.1038/35074631
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DOI: https://doi.org/10.1038/35074631
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