Abstract
Ezrin/radixin/moesin (ERM) proteins form crosslinks between cortical actin filaments and the plasma membrane. New findings indicate that they may also bind to the tumour-suppressor protein hamartin, thereby regulating Rho GTPases, the actin-based cytoskeleton and cell adhesion. Loss of hamartin function disrupts cell adhesion, which may contribute to the formation of tumours in individuals carrying hamartin mutations.
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Fukuhara, S., Gutkind, J. A new twist for the tumour suppressor hamartin. Nat Cell Biol 2, E76–E78 (2000). https://doi.org/10.1038/35010506
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DOI: https://doi.org/10.1038/35010506
