The detrimental effects of nuclear factor-kappa B (NF-κB) signalling in cancer cells lacking the oestrogen receptor have now become clear, with the demonstration that increased NF-κB levels induce expression of Bcl-2 to both suppress apoptosis and induce epithelial–mesenchymal transitions (EMTs).
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Radisky, D., Bissell, M. NF-κB links oestrogen receptor signalling and EMT. Nat Cell Biol 9, 361–363 (2007). https://doi.org/10.1038/ncb0407-361
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DOI: https://doi.org/10.1038/ncb0407-361
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