Nine inherited neurodegenerative disorders are caused by polyglutamine (polyQ) expansions in diverse proteins. A study now suggests that polyQ-mediated depletion of nonhistone chromatin proteins enhances genotoxic stress induced by the disease protein.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Qi, M. et al. Nature Cell Biol 9, 402–414 (2007).
Zoghbi, H. Y. & Orr, H. T. Annu. Rev. Neurosci. 23, 217–247 (2000).
Riley, B. E. & Orr, H. T. Genes Dev. 20, 2183–2192 (2006).
Butler, R. & Bates, G. P. Nature Rev. Neurosci. 7, 784–796 (2006).
Agresti, A. & Bianchi, M. E. Curr. Opin. Genet. Dev. 13, 170–178 (2003).
Lotze, M. T. & Tracey, K. J. Nature Rev. Immunol. 5, 331–342 (2005).
Ulloa, L. & Messmer, D. Cytokine Growth Factor Rev. 17, 189–201 (2006).
Hoshino, M. et al. J. Cell Biol. 172, 589–604 (2006).
Bae, B. I. et al. Neuron 47, 29–41 (2005).
Motoyama, N. & Naka, K. Curr. Opin. Genet. Dev. 14, 11–16 (2004).
Browne, S. E., Ferrante, R. J. & Beal, M. F. Brain Pathol. 9, 147–163 (1999).
Calogero, S. et al. Nature Genet. 22, 276–280 (1999).
Paulson, H. L. & Miller, V. M. Neuron 46, 845–848 (2005).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Todi, S., Paulson, H. Dangerous liaisons: polyglutamine meets HMGB. Nat Cell Biol 9, 359–361 (2007). https://doi.org/10.1038/ncb0407-359
Issue Date:
DOI: https://doi.org/10.1038/ncb0407-359
