To coordinate the coding complexity of the eukaryotic genome, mechanisms have evolved that protect active genes from silent chromatin structures such as heterochromatin. Although post-translational modifications of histone tails can regulate chromatin states, a new report now demonstrates that the composition of the nucleosome itself is also important for maintaining chromatin states.
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Hild, M., Paro, R. Anti-silencing from the core: a histone H2A variant protects euchromatin. Nat Cell Biol 5, 278–279 (2003). https://doi.org/10.1038/ncb0403-278
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DOI: https://doi.org/10.1038/ncb0403-278
