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A lethal giant kinase in cell polarity

Nature Cell Biology volume 5, pages 273–274 (2003)Cite this article

The coordinated action of several conserved multiprotein complexes establishes polarity in an asymmetrically dividing cell. How apically localized cues affect the basal distribution of proteins has remained unclear. However, new studies provides a direct link between the two poles, showing that the apical Par6–aPKC complex directly regulates Lethal giant larvae (Lgl).

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Figure 1: A model for directing asymmetry: Lgl is apically phosphorylated by aPKC.

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Authors and Affiliations

  1. Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, 94143-0725, CA, USA

    Nicholas J. Justice & Yuh Nung Jan

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  1. Nicholas J. Justice
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  2. Yuh Nung Jan
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Correspondence to Nicholas J. Justice.

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Justice, N., Jan, Y. A lethal giant kinase in cell polarity. Nat Cell Biol 5, 273–274 (2003). https://doi.org/10.1038/ncb0403-273

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