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Rb function in cell-cycle regulation and apoptosis

Nature Cell Biology volume 2, pages E65–E67 (2000)Cite this article

Abstract

Loss of cell-cycle control is a hallmark of neoplastic cells. One regulator of the critical G1 to S-phase transition in the cell cycle is the retinoblastoma tumour suppressor protein Rb, which interacts with the E2F family of cell-cycle transcription factors to repress gene transcription required for this transition. Through its interaction with E2F, Rb also regulates genes that control apoptosis. Here we review the roles of Rb in regulating the cell cycle and apoptosis and discuss recent results linking these Rb functions to chromatin-remodelling enzymes.

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Figure 1: The roles of the interactions of Rb with the E2F transcription factors and with chromatin-remodelling complexes in the regulation of the cell cycle and in apoptosis are still emerging.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Washington University, St Louis, 63110, Missouri, USA

    J. William Harbour

  2. Division of Molecular Oncology, Washington University, St Louis, 63110, Missouri, USA

    Douglas C. Dean

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  1. J. William Harbour
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  2. Douglas C. Dean
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Correspondence to Douglas C. Dean.

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Harbour, J., Dean, D. Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2, E65–E67 (2000). https://doi.org/10.1038/35008695

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