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Breaking the ties that bind centriole numbers

Newly formed centrioles can spring forth from clouds of pericentriolar material, violating the precise regulation of centriole counting. These observations challenge the long-standing view that centriole number is determined by the periodic activation of an assembly template thought to reside on pre-existing centrioles.

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Figure 1: Alternative routes for centriole duplication.
Figure 2: A unifying model for control of centriole number.

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Salisbury, J. Breaking the ties that bind centriole numbers. Nat Cell Biol 10, 255–257 (2008). https://doi.org/10.1038/ncb0308-255

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