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TAGing APP constrains neurogenesis

The cell adhesion molecule TAG1 has been identified as the ligand that induces β-amyloid precursor protein (APP) processing and signalling, resulting in the inhibition of neurogenesis. These findings demonstrate a critical role of TAG1–APP signalling in brain development and suggest the potential involvement of TAG1 in adult neuroplasticity and pathogenesis of Alzheimer's disease.

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Figure 1: Schematic representation of a model for the involvement of TAG1–APP signalling in regulation of neurogenesis.

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Mattson, M., van Praag, H. TAGing APP constrains neurogenesis. Nat Cell Biol 10, 249–250 (2008). https://doi.org/10.1038/ncb0308-249

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