The cell adhesion molecule TAG1 has been identified as the ligand that induces β-amyloid precursor protein (APP) processing and signalling, resulting in the inhibition of neurogenesis. These findings demonstrate a critical role of TAG1–APP signalling in brain development and suggest the potential involvement of TAG1 in adult neuroplasticity and pathogenesis of Alzheimer's disease.
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Mattson, M., van Praag, H. TAGing APP constrains neurogenesis. Nat Cell Biol 10, 249–250 (2008). https://doi.org/10.1038/ncb0308-249
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DOI: https://doi.org/10.1038/ncb0308-249
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Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer’s disease
Alzheimer's Research & Therapy (2018)