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RNA seeds nuclear bodies

Nature Cell Biology volume 13, pages 110–112 (2011)Cite this article

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The interior of the eukaryotic cell nucleus is populated by a multitude of microscopic domains termed nuclear bodies. Despite having attracted much attention, how these compartments form and are maintained remained elusive. Now, two live-cell imaging studies provide compelling evidence that nascent RNAs can act as transiently immobilized scaffolds that recruit specific nuclear body proteins.

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Figure 1: Tethering specific proteins and RNAs to a genomic locus.
Figure 2: Alternative models for nuclear body assembly.

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Authors and Affiliations

  1. Maria Carmo-Fonseca and José Rino are in the Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal. carmo.fonseca@fm.ul.pt,

    Maria Carmo-Fonseca & José Rino

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  1. Maria Carmo-Fonseca
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  2. José Rino
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Carmo-Fonseca, M., Rino, J. RNA seeds nuclear bodies. Nat Cell Biol 13, 110–112 (2011). https://doi.org/10.1038/ncb0211-110

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