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ERK and MDM2 prey on FOXO3a

Nature Cell Biology volume 10, pages 125–126 (2008)Cite this article

Constitutively active ERK signalling stimulates cell proliferation, thereby contributing to tumorigenesis. We now learn that ERK activity induces phosphorylation and MDM2-mediated degradation of the tumour-suppressing transcription factor FOXO3a, thus gaining new information on valuable targets for human cancer therapeutic intervention.

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Figure 1: Multiple signalling pathways inhibit the pro-apoptotic transcription factor FOXO3a.

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Authors and Affiliations

  1. Departments of Medicine (Hematology/Oncology), Wensheng Yang, Nathan G. Dolloff and Wafik S. El-Deiry are in the Laboratory of Molecular Oncology and Cell Cycle Regulation, Pharmacology, and Genetics, The Abramson Comprehensive Cancer Center, and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. wafik@mail.med.upenn.edu,

    Wensheng Yang, Nathan G. Dolloff & Wafik S. El-Deiry

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  1. Wensheng Yang
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  2. Nathan G. Dolloff
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  3. Wafik S. El-Deiry
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Yang, W., Dolloff, N. & El-Deiry, W. ERK and MDM2 prey on FOXO3a. Nat Cell Biol 10, 125–126 (2008). https://doi.org/10.1038/ncb0208-125

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