Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

INCENP at the kinase crossroads

INCENP — the targeting and activating subunit of Aurora B kinase— has several key mitotic functions. Now, INCENP emerges as a nodal point of the network of kinases that regulate mitotic events. Phosphorylation of INCENP by CDK1 is required for the kinetochore localization of Plk1 kinase, and this in turn is necessary for a timely metaphase–anaphase transition.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: INCENP integrates Plk1 and Aurora B signalling at kinetochores.
Figure 2

References

  1. Nigg, E.A. Nature Rev. Mol. Cell Biol. 2, 21–32 (2001).

    Article  CAS  Google Scholar 

  2. Carmena, M. & Earnshaw, W.C. Nature Rev. Mol. Cell Biol. 4, 842–854 (2003).

    Article  CAS  Google Scholar 

  3. Barr, F.A., Sillje, H.H. & Nigg, E.A. Nature Rev. Mol. Cell Biol. 5, 429–440 (2004).

    Article  CAS  Google Scholar 

  4. Goto, H. et al. Nature Cell Biol. 8, 180–187 (2006).

    Article  CAS  Google Scholar 

  5. Vagnarelli, P. & Earnshaw, W.C. Chromosoma 113, 211–222 (2004).

    Article  Google Scholar 

  6. Pereira, G. & Schiebel, E. Science 302, 2120–2124 (2003).

    Article  CAS  Google Scholar 

  7. Adams, R.R., Maiato, H., Earnshaw, W.C. & Carmena, M. J. Cell Biol. 153, 865–880 (2001).

    Article  CAS  Google Scholar 

  8. Adams, R.R. et al. Chromosoma 110, 65–74 (2001).

    Article  CAS  Google Scholar 

  9. Bishop, J.D. & Schumacher, J.M. J. Biol. Chem. 277, 27577–27580 (2002).

    Article  CAS  Google Scholar 

  10. Honda, R., Korner, R. & Nigg, E.A. Mol. Biol. Cell 14, 3325–3341 (2003).

    Article  CAS  Google Scholar 

  11. Gruss O.J & Vernos I. J. Cell Biol. 166, 949–955 (2004).

    Article  CAS  Google Scholar 

  12. Stukenberg P.T. et al. Curr. Biol. 7, 338–348 (1997).

    Article  CAS  Google Scholar 

  13. van Vugt, M. & Medema, R.H. Oncogene 24, 2844–2859 (2005).

    Article  CAS  Google Scholar 

  14. Acquaviva, C., Herzog, F., Kraft, C. & Pines, J. Nature Cell Biol. 6, 892–815 (2004).

    Article  CAS  Google Scholar 

  15. Wong O.K. & Fang, G. J. Cell Biol. 170, 709–719 (2004).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Carmena, M., Earnshaw, W. INCENP at the kinase crossroads. Nat Cell Biol 8, 110–111 (2006). https://doi.org/10.1038/ncb0206-110

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0206-110

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing