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The transcellular railway: insights into leukocyte diapedesis

Nature Cell Biology volume 8, pages 105–107 (2006)Cite this article

Leukocyte recruitment from blood to areas of infection is a key step in both innate and adaptive immunological responses. The predominant model has been that leukocytes transmigrate through the junctions between adjacent endothelial cells. However, leukocytes can also migrate through the endothelial cells, and new insights suggest that both caveolae and intermediate filaments are important for this.

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Figure 1: Diapedesis of leukocytes through endothelial cell junctions.
Figure 2: Leukocytes can cross the endothelium by penetrating the cell cytoplasm.

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  1. Department of Biomolecular Sciences and Biotechnology, Faculty of Sciences, University of Milan and FIRC Institute of Molecular Oncology, Milan, Italy

    Elisabetta Dejana

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  1. Elisabetta Dejana
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Dejana, E. The transcellular railway: insights into leukocyte diapedesis. Nat Cell Biol 8, 105–107 (2006). https://doi.org/10.1038/ncb0206-105

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