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New therapies from old medicines

Although new botanical drugs pose many challenges for both industry and the FDA, approval of the first botanical prescription drug shows they can be successfully met.

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References

  1. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research. Guidance for Industry. Botanical Drug Products (FDA, DC, June 2004). <http://www.fda.gov/cder/guidance/4592fnl.pdf>

  2. http://www.fda.gov/opacom/laws/DSHEA.html

  3. http://www.cfsan.fda.gov/dms/dscgmps6.html

  4. Wu, K.M. et al. Toxicol. Lett. 111, 199–202 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Wu, K.M. et al. Am. J. Ther. 11, 213–217 (2004).

    Article  PubMed  Google Scholar 

  6. http://www.emea.europa.eu/pdfs/human/hmpc/31494706en.pdf

  7. http://www.fda.gov/cder/mapp/6007.1.pdf

  8. http://www.emea.europa.eu/pdfs/human/hmpc/003199en.pdf

  9. Murayama, M., Takao, M., Bando, H. & Amiya, T. J. Ethnopharmacol. 35, 159–164 (1991).

    Article  CAS  PubMed  Google Scholar 

  10. http://www.emea.europa.eu/pdfs/human/hmpc/21486906enfin.pdf

  11. Lindenmuth, G.F. & Lindenmuth, E.B. J. Altern. Complement. Med. 6, 327–334 (2000).

    Article  CAS  PubMed  Google Scholar 

  12. Turner, R.B., Bauer, R., Woelkart, K., Hulsey, T.C. & Gangemi, J.D. N. Engl. J. Med. 353, 341–348 (2005).

    Article  CAS  PubMed  Google Scholar 

  13. Hypericum Depression Trial Study Group. J. Am. Med. Assoc. 287, 1807–1814 (2002).

  14. Shelton, R.C. et al. J. Am. Med. Assoc. 285, 1978–1986 (2001).

    Article  CAS  Google Scholar 

  15. Kasper, S., Anghelescu, I.G., Szegedi, A., Dienel, A. & Kieser, M. BMC Med. 4, 14 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  16. Nakachi, K., Eguchi, H. & Imai, K. Ageing Res. Rev. 2, 1–10 (2003).

    Article  PubMed  Google Scholar 

  17. Lin, Y.S., Tsai, Y.J., Tsay, J.S. & Lin, J.K. J. Agric. Food Chem. 51, 1864–1873 (2003).

    Article  CAS  PubMed  Google Scholar 

  18. Jiang, X. New Medical College, Encyclopedia of Chinese Materia Medica (Zhong Yao Da Ci Dian) (Shanghai People's Press, Shanghai, China, 1977).

  19. Stevens, T., Qadri, A. & Zein, N.N. Ann. Intern. Med. 142, 477–478 (2005).

    Article  PubMed  Google Scholar 

  20. Gloro, R. et al. Eur. J. Gastroenterol. Hepatol. 17, 1135–1137 (2005).

    Article  PubMed  Google Scholar 

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The authors thank L. Vaccari for assistance in preparing an early draft.

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Chen, S., Dou, J., Temple, R. et al. New therapies from old medicines. Nat Biotechnol 26, 1077–1083 (2008). https://doi.org/10.1038/nbt1008-1077

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