The production of specific glycosidic linkages in complex carbohydrates and glycoconjugates is a significant challenge to synthetic chemists, requiring laborious protection strategies and lengthy sequences of reactions. Recently, several synthetic methods have been adopted that broaden the range of glycoconjugates available for production on a large scale. On p. 835, Koeller and Wong describe new approaches for producing complex carbohydrates and outline how they are being exploited to synthesize antivirals, antimicrobials, and immunomodulators. They also highlight the need for further studies to identify a greater range of enzymes involved in glycosidic linkage, improve glycoform heterogeneity, and automate production methods.