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Ordering Up Big MACs

Abstract

Both gene therapy and basic studies will need new vectors for the transfer of large fragments of mammalian DNA

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References

  1. Cohen, D., Chumakov, I., and Weissenbach, J. 1993. Nature 366: 698–701.

    Article  CAS  Google Scholar 

  2. Murray, A.W. and Szostak, J.W. 1983. Nature 305: 189–193.

    Article  CAS  Google Scholar 

  3. Neil, D.L., et al. 1990 Nucl. Acids Res. 18: 1421–1428.

    Article  CAS  Google Scholar 

  4. Brown, W.R.A. 1992. Curr. Opin. Gen. Dev. 2: 479–486.

    Article  CAS  Google Scholar 

  5. Featherstone, T. and Huxley, C. 1993. Genomics 17: 267–278.

    Article  CAS  Google Scholar 

  6. Nonet, G.H. and Wahl, G.M. 1993. Somat. Cell Mol. Genet. 19: 171–192.

    Article  CAS  Google Scholar 

  7. Lamb, B.T., et al. 1993 Nature Genet. 5: 22–29.

    Article  CAS  Google Scholar 

  8. Biessman, H. and Mason, J.M. 1992. Adv. Genet. 30: 185–249.

    Article  Google Scholar 

  9. Blackburn, E.H. 1991. Nature 350: 569–573.

    Article  CAS  Google Scholar 

  10. Kipling, D. and Cooke, H.J. 1992. Hum. Mol. Genet. 1: 3–6.

    Article  CAS  Google Scholar 

  11. Blackburn, E.H. 1992. Annu. Rev. Biochem. 61: 113–129.

    Article  CAS  Google Scholar 

  12. Broccoli, D. and Cooke, H.J. 1993. Am. J. Hum. Genet. 52: 657–660.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Szostak, J. and Blackburn, E.H. 1982. Cell 29: 245–255.

    Article  CAS  Google Scholar 

  14. Lamb, J., et al. 1993 Am. J. Hum. Genet. 52: 668–676.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Farr, C.J., et al. 1991 Proc. Natl Acad. Sci. USA 88: 7006–7010.

    Article  CAS  Google Scholar 

  16. Barnett, M.A., et al. 1993 Nucleic Acids Res. 21: 27–36.

    Article  CAS  Google Scholar 

  17. Farr, C.J., et al. 1992 Nature Genet. 2: 275–282.

    Article  CAS  Google Scholar 

  18. Itzhaki, J.E., et al. 1992 Nature Genet. 2: 283–287.

    Article  CAS  Google Scholar 

  19. DePamphilis, M.L. 1993. Annu. Rev. Biochem. 62: 29–63.

    Article  CAS  Google Scholar 

  20. Umek, R.M., et al. 1989 Biochim. Biophys. Acta 1007: 1–14.

    Article  CAS  Google Scholar 

  21. Newlon, C.S. 1993. Science 262: 1830–1831.

    Article  CAS  Google Scholar 

  22. Marahrens, Y. and Stillman, B. 1992. Science 255: 817–823.

    Article  CAS  Google Scholar 

  23. Linskens, M.H.K. and Huberman, J.A. 1990. Cell 62: 845–847.

    Article  CAS  Google Scholar 

  24. DePamphilis, M.L. 1993. J. Biol. Chem. 268: 1–4.

    CAS  PubMed  Google Scholar 

  25. Burhans, W.C. and Huberman, J.A. 1994. Science 263: 639–640.

    Article  CAS  Google Scholar 

  26. Vassilev, L.T. and DePhamphilis, M.L. 1992. Crit. Rev. Biochem. Mol. Biol. 27: 445–472.

    Article  CAS  Google Scholar 

  27. Brinkly, B.R., et al. 1989 Mitosis: Molecules and Mechanisms. J.S Hyams, B.R. Brinkley, Eds., 77–118, Academic Press.

    Google Scholar 

  28. Pluta, A.F., et al. 1990 Trends Biochem Sci. l5: 181–185.

    Article  Google Scholar 

  29. Willard, H.F. 1990. Trends Genet. 6: 410–416.

    Article  CAS  Google Scholar 

  30. Miklos, G.L.G. 1985. Molecular Evolutionary Genetics. R.J. MacIntyre, Ed. 241–321, Plenum Press.

    Book  Google Scholar 

  31. Manuelidis, L. 1976. Nucl. Acids Res. 3: 3063–3076.

    Article  CAS  Google Scholar 

  32. Willard, H.F. and Waye, J.S. 1987. Trends Genet. 3: 192–198.

    Article  CAS  Google Scholar 

  33. Warburton, P.E. and Willard, H.F. 1990. J. Mol. Biol. 216: 3–16.

    Article  CAS  Google Scholar 

  34. Haaf, T., et al. 1992 Cell 70: 681–696.

    Article  CAS  Google Scholar 

  35. Willard, H.F. 1992. Hum. Mol. Genet. 1: 667–668.

    Article  CAS  Google Scholar 

  36. Tyler-Smith, C. and Willard, H.F. 1993. Curr. Opin. Genet. Develop. 3: 390–397.

    Article  CAS  Google Scholar 

  37. Clarke, K. 1990. Trends Genet. 6: 150–154.

    Article  CAS  Google Scholar 

  38. Steiner, N.C., et al. 1993 Mol. Cell Biol. 13: 4578–4587.

    Article  CAS  Google Scholar 

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Huxley, C., Farr, C., Gennaro, M. et al. Ordering Up Big MACs. Nat Biotechnol 12, 586–590 (1994). https://doi.org/10.1038/nbt0694-586

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