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Knockdown by RNAi—proceed with caution

Nature Biotechnology volume 22, pages 280–282 (2004)Cite this article

Small interfering RNAs, synthesized using phage polymerases but not by chemical methods, can trigger the interferon response in mammalian cells.

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Figure 1: Mechanisms by which dsRNA functions as a molecular trigger to mediate changes in gene expression patterns.

Bob Crimi

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  1. Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, 93106, California, USA

    Charles E Samuel

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  1. Charles E Samuel
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Samuel, C. Knockdown by RNAi—proceed with caution. Nat Biotechnol 22, 280–282 (2004). https://doi.org/10.1038/nbt0304-280

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