Kalos, M. et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci. Transl. Med. 3, 95ra73 (2011).
Porter, D.L., Levine, B.L., Kalos, M., Bagg, A. & June, C.H. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N. Engl. J. Med. 365, 725–733 (2011).
Kochenderfer, J.N. et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood 116, 4099–4102 (2010).
Chapuis, A.G. et al. Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients. Sci. Transl. Med. 5, 174ra27 (2013).
Chapuis, A.G. et al. Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype. Proc. Natl. Acad. Sci. USA 109, 4592–4597 (2012).
Morgan, R.A. et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314, 126–129 (2006).
Dudley, M.E. et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J. Clin. Oncol. 26, 5233–5239 (2008).
Robbins, P.F. et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J. Clin. Oncol. 29, 917–924 (2011).
Stromnes, I.M. et al. Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo. J. Immunol. 189, 1812–1825 (2012).
Schmitt, T.M., Ragnarsson, G.B. & Greenberg, P.D. T cell receptor gene therapy for cancer. Hum. Gene Ther. 20, 1240–1248 (2009).
Garrido, F., Aptsiauri, N., Doorduijn, E.M., Garcia Lora, A.M. & van Hall, T. The urgent need to recover MHC class I in cancers for effective immunotherapy. Curr. Opin. Immunol. 39, 44–51 (2016).
Udyavar, A., Alli, R., Nguyen, P., Baker, L. & Geiger, T.L. Subtle affinity-enhancing mutations in a myelin oligodendrocyte glycoprotein-specific TCR alter specificity and generate new self-reactivity. J. Immunol. 182, 4439–4447 (2009).
Zhao, Y. et al. High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines. J. Immunol. 179, 5845–5854 (2007).
Richman, S.A. & Kranz, D.M. Display, engineering, and applications of antigen-specific T cell receptors. Biomol. Eng. 24, 361–373 (2007).
Wucherpfennig, K.W., Gagnon, E., Call, M.J., Huseby, E.S. & Call, M.E. Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. Cold Spring Harb. Perspect. Biol. 2, a005140 (2010).
Huseby, E.S., Crawford, F., White, J., Marrack, P. & Kappler, J.W. Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nat. Immunol. 7, 1191–1199 (2006).
Stadinski, B.D. et al. A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands. Immunity 35, 694–704 (2011).
Wang, J.-H. & Reinherz, E.L. The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function. Immunol. Rev. 250, 102–119 (2012).
Cameron, B.J. et al. Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells. Sci. Transl. Med. 5, 197ra103 (2013).
Linette, G.P. et al. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. Blood 122, 863–871 (2013).
von Boehmer, H. et al. Pleiotropic changes controlled by the pre-T-cell receptor. Curr. Opin. Immunol. 11, 135–142 (1999).
Pennington, D.J., Silva-Santos, B. & Hayday, A.C. Gammadelta T cell development--having the strength to get there. Curr. Opin. Immunol. 17, 108–115 (2005).
Terrence, K., Pavlovich, C., Matechak, E. & Fowlkes, B. Premature expression of T cell receptor (TCR)αβ suppresses TCRγδ gene rearrangement but permits development of γδ lineage T cells. J. Exp. Med. 192, 537–548 (2000).
Egawa, T., Kreslavsky, T., Littman, D. & von Boehmer, H. Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. PLoS One 3, 1512 (2008).
Baldwin, T.A., Sandau, M.M., Jameson, S.C. & Hogquist, K.A. The timing of TCR alpha expression critically influences T cell development and selection. J. Exp. Med. 202, 111–121 (2005).
von Boehmer, H., Kirberg, J. & Rocha, B. An unusual lineage of α/β T cells that contains autoreactive cells. J. Exp. Med. 174, 1001–1008 (1991).
Schmitt, T.M. & Zúñiga-Pflücker, J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17, 749–756 (2002).
Schmitt, T.M. & Zúñiga-Pflücker, J.C. T-cell development, doing it in a dish. Immunol. Rev. 209, 95–102 (2006).
Schmitt, T.M. et al. Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat. Immunol. 5, 410–417 (2004).
Hogquist, K.A., Jameson, S.C. & Bevan, M.J. Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells. Immunity 3, 79–86 (1995).
Page, D.M., Kane, L.P., Allison, J.P. & Hedrick, S.M. Two signals are required for negative selection of CD4+CD8+ thymocytes. J. Immunol. 151, 1868–1880 (1993).
Schmitt, T.M. et al. Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection. Blood 122, 348–356 (2013).
Chervin, A.S., Aggen, D.H., Raseman, J.M. & Kranz, D.M. Engineering higher affinity T cell receptors using a T cell display system. J. Immunol. Methods 339, 175–184 (2008).
Buckler, A.J., Pelletier, J., Haber, D.A., Glaser, T. & Housman, D.E. Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol. Cell. Biol. 11, 1707–1712 (1991).
Scharnhorst, V., van der Eb, A.J. & Jochemsen, A.G. WT1 proteins: functions in growth and differentiation. Gene 273, 141–161 (2001).
Holst, J., Vignali, K.M., Burton, A.R. & Vignali, D.A. Rapid analysis of T-cell selection in vivo using T cell–receptor retrogenic mice. Nat. Methods 3, 191–197 (2006).
Smith, T.R.F., Verdeil, G., Marquardt, K. & Sherman, L.A. Contribution of TCR signaling strength to CD8+ T cell peripheral tolerance mechanisms. J. Immunol. 193, 3409–3416 (2014).
Robins, H.S. et al. Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells. Blood 114, 4099–4107 (2009).
Snauwaert, S. et al. In vitro generation of mature, naive antigen-specific CD8+ T cells with a single T-cell receptor by agonist selection. Leukemia 28, 830–841 (2013).
Van Coppernolle, S. et al. Functionally mature CD4 and CD8 TCRαβ cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells. J. Immunol. 183, 4859–4870 (2009).
Liu, B. et al. 2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system. Eur. J. Immunol. 44, 239–250 (2014).
Huang, J. et al. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. Nature 464, 932–936 (2010).
Li, Y. et al. Directed evolution of human T-cell receptors with picomolar affinities by phage display. Nat. Biotechnol. 23, 349–354 (2005).
Holler, P.D. et al. In vitro evolution of a T cell receptor with high affinity for peptide/MHC. Proc. Natl. Acad. Sci. USA 97, 5387–5392 (2000).
Jones, L.L., Colf, L.A., Stone, J.D., Garcia, K.C. & Kranz, D.M. Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation. J. Immunol. 181, 6255–6264 (2008).
Hunder, N.N. et al. Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. N. Engl. J. Med. 358, 2698–2703 (2008).
Tran, E. et al. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344, 641–645 (2014).
Schmitt, T.M., Stromnes, I.M., Chapuis, A.G. & Greenberg, P.D. New strategies in engineering T-cell receptor gene-modified t cells to more effectively target malignancies. Clin. Cancer Res. 21, 5191–5197 (2015).
Stone, J.D. & Kranz, D.M. Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies. Front. Immunol. 4, 244 (2013).
Mehrotra, S. et al. A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice. J. Immunol. 189, 1627–1638 (2012).
Fujiwara, H. et al. Antileukemia multifunctionality of CD4+ T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer. Leukemia 29, 2393–2401 (2015).
Brochet, X., Lefranc, M.-P. & Giudicelli, V. IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 36, W503–W508 (2008).
Giudicelli, V., Brochet, X. & Lefranc, M.-P. IMGT/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences. Cold Spring Harb. Protoc. 2011, pdb.prot5633 (2011).
Letourneur, F. & Malissen, B. Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α-mRNA of BW5147 origin. Eur.J.Immunol. 19, 2269–2274 (1989).