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Reigning in regulatory T-cell function

Nature Biotechnology volume 33, pages 718–719 (2015)Cite this article

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An approach to inhibit the immune-suppressive function of regulatory T cells is demonstrated in a model of graft-versus-host disease.

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Figure 1: On the Treg cell surface, the latent form of TGF-β1 is bound to membrane protein GARP.

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Authors and Affiliations

  1. Catherine Konopacki, George Plitas & Alexander Rudensky are at the Howard Hughes Medical Institute and Immunology Program, Ludwig Center,

    Catherine Konopacki, George Plitas & Alexander Rudensky

  2. Department of Surgery, George Plitas is also at the Breast Cancer Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.,

    George Plitas

Authors
  1. Catherine Konopacki
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  2. George Plitas
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  3. Alexander Rudensky
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Corresponding author

Correspondence to Alexander Rudensky.

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Competing interests

A.R. is a consultant for Surface Oncology, FLX Bio, Inc., and Vedanta Biosciences.

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Konopacki, C., Plitas, G. & Rudensky, A. Reigning in regulatory T-cell function. Nat Biotechnol 33, 718–719 (2015). https://doi.org/10.1038/nbt.3285

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