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Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading

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Figure 1: Efficacy and pharmacokinetics of ADCs with different loading.
Figure 2: Clustering of hydrophobic payloads on higher-loaded ADCs and their corresponding pharmacokinetics in rat.

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Acknowledgements

We thank D. McDonough and C. Samain for their help with PK experiments, G. Bolton for technical assistance and T. Kuo and O.-K. Wong for reading the manuscript.

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Correspondence to Pavel Strop or Arvind Rajpal.

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All authors are employees of Pfizer, Inc.

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Supplementary Figures 1–8, and Supplementary Tables 1–3, and Supplemental Experimental Procedures (PDF 5728 kb)

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Strop, P., Delaria, K., Foletti, D. et al. Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading. Nat Biotechnol 33, 694–696 (2015). https://doi.org/10.1038/nbt.3274

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