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Taking charge of siRNA delivery

Nature Biotechnology volume 32, pages 1197–1198 (2014)Cite this article

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A Corrigendum to this article was published on 12 May 2015

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Delivery of siRNA into cells is achieved by neutralizing the negative charge of the phosphate backbone in a reversible manner.

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Figure 1: Internalization and cellular processing of TAT-conjugated siRNN.

Change history

  • 29 April 2015

    In the version of this article initially published, in two instances molecules were misidentified in the text. The last sentence in the legend of Figure 1 should have read, “a charged phosphodiester,” rather than “a phosphatediester.” On p.1197, third column, first paragraph, “intracellular phosphodiesterases….” should have read, “intracellular thioesterases….” The errors have been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA

    Anastasia Khvorova, Maire F Osborn & Matthew R Hassler

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  1. Anastasia Khvorova
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  2. Maire F Osborn
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  3. Matthew R Hassler
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Correspondence to Anastasia Khvorova.

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The authors declare no competing financial interests.

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Khvorova, A., Osborn, M. & Hassler, M. Taking charge of siRNA delivery. Nat Biotechnol 32, 1197–1198 (2014). https://doi.org/10.1038/nbt.3091

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