Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

A three-dimensional human neural cell culture model of Alzheimer's disease

Choi, S.H. et al. Nature 515, 274–278 (2014)

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

Buffie, C.G. et al. Nature doi:10.1038/nature13828 (22 October 2014)

Chimeric antigen receptor T cells for sustained remissions in leukemia

Maude, S.L. et al. N. Engl. J. Med. 371, 1507–1517 (2014)

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

Platt, R.J. et al. Cell 159, 440–455 (2014)

Dominant drug targets suppress the emergence of antiviral resistance

Tanner, E.J. et al. eLife doi:10.7554/eLife.03830 (3 November 2014)