Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A blueprint of cell identity

Research on converting one cell type to another will be aided by systematic mapping of the gene-regulatory networks in mammalian cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Gene-expression data from 11 samples corresponding to five cell types—colon, fetal liver, adult liver, induced hepatocyte (iHep) and colon-engrafted induced hepatocyte—profiled in one of the CellNet studies2 were downloaded from GEO (GSE59037).

Accession codes

Accessions

Gene Expression Omnibus

References

  1. Cahan, P. et al. Cell 158, 903–915 (2014).

    Article  CAS  Google Scholar 

  2. Morris, S.A. et al. Cell 158, 889–902 (2014).

    Article  CAS  Google Scholar 

  3. Waddington, C.H. The Strategy of the Genes (Routledge, 2014).

  4. Xu, H., Schaniel, C., Lemischka, I.R. & Ma'ayan, A. Wiley Interdiscip. Rev. Syst. Biol. Med. 2, 708–733 (2010).

    Article  CAS  Google Scholar 

  5. Xu, H., Ang, Y.-S., Sevilla, A., Lemischka, I.R. & Ma'ayan, A. PLOS Comput. Biol. 10, e1003777 (2014).

    Article  Google Scholar 

  6. Dunn, S.-J., Martello, G., Yordanov, B., Emmott, S. & Smith, A. Science 344, 1156–1160 (2014).

    Article  CAS  Google Scholar 

  7. Qiu, P. et al. Nat. Biotechnol. 29, 886–891 (2011).

    Article  CAS  Google Scholar 

  8. Sekiya, S. & Suzuki, A. Nature 475, 390–393 (2011).

    Article  CAS  Google Scholar 

  9. Faith, J.J. et al. PLoS Biol. 5, e8 (2007).

    Article  Google Scholar 

  10. Ma'ayan, A. et al. Trends Pharmacol. Sci. 35, 450–460 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Avi Ma'ayan.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ma'ayan, A., Duan, Q. A blueprint of cell identity. Nat Biotechnol 32, 1007–1008 (2014). https://doi.org/10.1038/nbt.3035

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3035

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing