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Interactive visualization and analysis of large-scale sequencing datasets using ZENBU

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Figure 1: Overview of ZENBU genome browser interface showcasing several on-demand processing tracks of selected ENCODE project experiments related to Gm12878, HeLa and Nhek cell lines.

References

  1. Chadwick, L.H. Epigenomics 4, 317–324 (2012).

    Article  CAS  Google Scholar 

  2. The ENCODE Project Consortium. Nature 489, 57–74 (2012).

  3. Li, H. et al. Bioinformatics 25, 2078–2079 (2009).

    Article  Google Scholar 

  4. Nielsen, C.B., Cantor, M., Dubchak, I., Gordon, D. & Wang, T. Nat. Methods 7, S5–S15 (2010).

    Article  CAS  Google Scholar 

  5. Saito, T.L. et al. Bioinformatics 25, 1856–1861 (2009).

    Article  CAS  Google Scholar 

  6. Stein, L.D. et al. Genome Res. 12, 1599–1610 (2002).

    Article  CAS  Google Scholar 

  7. Kuhn, R.M., Haussler, D. & Kent, W.J. Brief. Bioinform. 14, 144–161 (2013).

    Article  CAS  Google Scholar 

  8. Hubbard, T. et al. Nucleic Acids Res. 30, 38–41 (2002).

    Article  CAS  Google Scholar 

  9. Robinson, J.T. et al. Nat. Biotechnol. 29, 24–26 (2011).

    Article  CAS  Google Scholar 

  10. Zhang, J. et al. Database (Oxford) 2011, bar038 (2011).

    Google Scholar 

  11. Derrien, T. et al. Genome Res. 22, 1775–1789 (2012).

    Article  CAS  Google Scholar 

  12. Frith, M.C. et al. Genome Res. 18, 1–12 (2008).

    Article  CAS  Google Scholar 

  13. Wei, G. et al. Immunity 35, 299–311 (2011).

    Article  CAS  Google Scholar 

  14. Severin, J. et al. BMC Bioinformatics 11, 240 (2010).

    Article  Google Scholar 

  15. Carninci, P. et al. Science 309, 1559–1563 (2005).

    Article  CAS  Google Scholar 

  16. Suzuki, H. et al. Nat. Genet. 41, 553–562 (2009).

    Article  CAS  Google Scholar 

  17. Contrino, S. et al. Nucleic Acids Res. 40, D1082–D1088 (2012).

    Article  CAS  Google Scholar 

  18. Giardine, B. et al. Genome Res. 15, 1451–1455 (2005).

    Article  CAS  Google Scholar 

  19. The Cancer Genome Atlas Research Network et al. Nat. Genet. 45, 1113–1120 (2013).

Download references

Acknowledgements

We would like to acknowledge C. Plessy, P. Carninci and the FANTOM5 consortium members for critical feedback during development of the system. The work was funded by a research grant for RIKEN Omics Science Center from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) to Y.H. and a grant of the Innovative Cell Biology by Innovative Technology (Cell Innovation Program) from the MEXT, Japan to Y.H. This study is also supported by Research Grants from MEXT through RIKEN Preventive Medicine and Diagnosis Innovation Program to Y.H. and RIKEN Center for Life Science Technologies, Division of Genomic Technologies to Piero Carninci.

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Correspondence to Nicolas Bertin or Alistair R R Forrest.

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Severin, J., Lizio, M., Harshbarger, J. et al. Interactive visualization and analysis of large-scale sequencing datasets using ZENBU. Nat Biotechnol 32, 217–219 (2014). https://doi.org/10.1038/nbt.2840

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