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Staying on target with CRISPR-Cas

Four independent studies shed light on the specificity of RNA-guided genome editing tools based on the Streptococcus pyogenes Cas9 protein.

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Figure 1: The sgRNA:Cas9 targeting complex.

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Correspondence to Dana Carroll.

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Carroll, D. Staying on target with CRISPR-Cas. Nat Biotechnol 31, 807–809 (2013). https://doi.org/10.1038/nbt.2684

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