Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Single-cell sequencing in its prime

Nature Biotechnology volume 31, pages 211–212 (2013)Cite this article

Subjects

A new method for amplifying DNA allows more-uniform sequencing coverage of the genome of a single cell.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Simplified diagram of the MALBAC reaction.

Katie Vicari

References

  1. Wang, J., Fan, H.C., Behr, B. & Quake, S.R. Cell 150, 402–412 (2012).

    Article  CAS  Google Scholar 

  2. Caldas, C. Nat. Biotechnol. 30, 408–410 (2012).

    Article  CAS  Google Scholar 

  3. Evrony, G.D. Cell 151, 483–496 (2012)

    Article  CAS  Google Scholar 

  4. Zong, C., Lu, S., Chapman, A.R. & Xie, X.S. Science 338, 1622–1626 (2012).

    Article  CAS  Google Scholar 

  5. Dean, F.B., Nelson, J.R., Giesler, T.L. & Lasken, R.S. Genome Res. 11, 1095–1099 (2001).

    Article  CAS  Google Scholar 

  6. Dean, F.B. et al. Proc. Natl. Acad. Sci. USA 99, 5261–5266 (2002).

    Article  CAS  Google Scholar 

  7. Lasken, R.S. Nat. Rev. Microbiol. 10, 631–640 (2012).

    Article  CAS  Google Scholar 

  8. Gundry, M., Li, W., Maqbool, S.B. & Vijg, J. Nucleic Acids Res. 40, 2032–2040 (2012).

    Article  CAS  Google Scholar 

  9. Hou, Y. et al. Cell 148, 873–885 (2012).

    Article  CAS  Google Scholar 

  10. Lasken, R.S. & Stockwell, T. BMC Biotechnol. 7, 19 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Roger S. Lasken is at the J. Craig Venter Institute, San Diego, California, USA.,

    Roger S Lasken

Authors
  1. Roger S Lasken
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Roger S Lasken.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lasken, R. Single-cell sequencing in its prime. Nat Biotechnol 31, 211–212 (2013). https://doi.org/10.1038/nbt.2523

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2523

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing