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Smooth muscle diversity from human pluripotent cells

A method for differentiating human pluripotent stem cells into several subtypes of smooth muscle cell should aid the study and treatment of vascular disease.

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Figure 1: Derivation of origin-specific vascular smooth muscle cells from human pluripotent stem cells (hPSCs).

References

  1. DeBakey, M.E. & Glaeser, D. Am. J. Cardiol. 85, 1045–1053 (2000).

    Article  CAS  Google Scholar 

  2. Cheung, C. et al. Nat. Biotechnol. 30, 165–173 (2012).

    Article  CAS  Google Scholar 

  3. Majesky, M.W. Arterioscler. Thromb. Vasc. Biol. 27, 1248–1258 (2007).

    Article  CAS  Google Scholar 

  4. Topouzis, S. & Majesky, M.W. Dev. Biol. 178, 430–445 (1996).

    Article  CAS  Google Scholar 

  5. Gadson, P.F. Jr. et al. Exp. Cell Res. 230, 169–180 (1997).

    Article  CAS  Google Scholar 

  6. Owens, A.P. III et al. Circ. Res. 106, 611–619 (2010).

    Article  CAS  Google Scholar 

  7. Jaffe, M. et al. Arterioscler. Thromb. Vasc. Biol. 32, e1–e11 (2012).

    Article  CAS  Google Scholar 

  8. Waldo, K. & Kirby, M. Anat. Rec. 237, 385–399 (1993).

    Article  CAS  Google Scholar 

  9. Bergwerff, M. et al. Circ. Res. 82, 221–231 (1998).

    Article  CAS  Google Scholar 

  10. Jiang, X. et al. Development 127, 1607–1616 (2000).

    CAS  PubMed  Google Scholar 

  11. Wasteson, P. et al. Development 135, 1823–1832 (2008).

    Article  CAS  Google Scholar 

  12. Haimovici, H. Tex. Heart Inst. J. 18, 81–83 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Lindsay, M.E. & Dietz, H.C. Nature 473, 308–316 (2011).

    Article  CAS  Google Scholar 

  14. Leroux-Berger, M. et al. J. Bone Miner. Res. 26, 1543–1553 (2011).

    Article  CAS  Google Scholar 

  15. LeMaire, S.A. et al. Nat. Genet. 43, 996–1000 (2011).

    Article  CAS  Google Scholar 

  16. Bernardo, A.S. et al. Cell Stem Cell 9, 144–155 (2011).

    Article  CAS  Google Scholar 

  17. Dosch, R. et al. Development 124, 2325–2334 (1997).

    CAS  PubMed  Google Scholar 

  18. Vallier, L. et al. PLoS ONE 4, e6082 (2009).

    Article  Google Scholar 

  19. Wang, D.Z. et al. Cell 105, 851–862 (2001).

    Article  CAS  Google Scholar 

  20. Li, J. et al. Proc. Natl. Acad. Sci. USA 102, 8916–8921 (2005).

    Article  CAS  Google Scholar 

  21. Oh, J. et al. Proc. Natl. Acad. Sci. USA 102, 15122–15127 (2005).

    Article  CAS  Google Scholar 

  22. Koch, P. et al. Lancet Neurol. 8, 819–829 (2009).

    Article  Google Scholar 

Download references

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Correspondence to Mark W Majesky or Christine L Mummery.

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Majesky, M., Mummery, C. Smooth muscle diversity from human pluripotent cells. Nat Biotechnol 30, 152–154 (2012). https://doi.org/10.1038/nbt.2117

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