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Neurodegenerative disease

Two–for–one on potential therapies

Molecules that inhibit the synthesis of the ataxin 2 protein can ameliorate the effects of two neurodegenerative diseases in mouse models, raising hopes for the success of this approach in clinical trials. See Letters p.362 & p.367

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Figure 1: A shared strategy for treating two neurodegenerative diseases.

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References

  1. Scoles, D. R. et al. Nature 544, 362–366 (2017).

    Article  ADS  CAS  Google Scholar 

  2. Becker, L. A. et al. Nature 544, 367–371 (2017).

    Article  ADS  CAS  Google Scholar 

  3. Pulst, S.-M. et al. Nature Genet. 14, 269–276 (1996).

    Article  CAS  Google Scholar 

  4. Elden, A. C. et al. Nature 466, 1069–1075 (2010).

    Article  ADS  CAS  Google Scholar 

  5. Sephton, C. F. et al. J. Biol. Chem. 285, 6826–6834 (2010).

    Article  CAS  Google Scholar 

  6. Kiehl, T.-R. et al. Biochem. Biophys. Res. Commun. 339, 17–24 (2006).

    Article  CAS  Google Scholar 

  7. Ramaswami, M., Taylor, J. P. & Parker, R. Cell 154, 727–736 (2013).

    Article  CAS  Google Scholar 

  8. Finkel, R. S. et al. Lancet 388, 3017–3026 (2016).

    Article  CAS  Google Scholar 

  9. Hua, Y. et al. Nature 478, 123–126 (2011).

    Article  ADS  CAS  Google Scholar 

  10. DeVos, S. L. & Miller, T. M. Neurotherapeutics 10, 486–497 (2013).

    Article  CAS  Google Scholar 

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Correspondence to Ke Zhang or Jeffrey D. Rothstein.

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Zhang, K., Rothstein, J. Two–for–one on potential therapies. Nature 544, 302–303 (2017). https://doi.org/10.1038/nature21911

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