Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Physiology

Bone-derived hormone suppresses appetite

Nature volume 543, pages 320–321 (2017)Cite this article

Subjects

The glycoprotein lipocalin 2 is released from the bones of mice in a nutrient-dependent manner and binds to receptors in the brain to suppress appetite. This is the first example of bone-derived signals mediating hunger. See Article p.385

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A bone–brain axis modulates hunger.

Notes

  1. See all news & views

References

  1. Mosialou, I. et al. Nature 543, 385–390 (2017).

    Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

  2. Ferreira, A. C. et al. Prog. Neurobiol. 131, 120–136 (2015).

    Article  CAS  PubMed  Google Scholar 

  3. Flo, T. H. et al. Nature 432, 917–921 (2004).

    Article  CAS  ADS  PubMed  Google Scholar 

  4. Flower, D. R. FEBS Lett. 354, 7–11 (1994).

    Article  CAS  PubMed  Google Scholar 

  5. Cone, R. D. Endocrine Rev. 27, 736–749 (2006).

    Article  CAS  Google Scholar 

  6. Farooqi, I. S. & O'Rahilly, S. Nature Clin. Pract. Endocrinol. Metab. 4, 569–577 (2008).

    Article  CAS  Google Scholar 

  7. Campos, C. A., Shiina, H. & Ritter, R. C. J. Neurosci. 34, 12636–12645 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Roman, C. W., Derkach, V. A. & Palmiter, R. D. Nature Commun. 7, 11905 (2016).

    Article  CAS  ADS  Google Scholar 

  9. Liu, Y. et al. Endocrinology 157, 2380–2392 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Richard D. Palmiter is at the Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.,

    Richard D. Palmiter

Authors
  1. Richard D. Palmiter
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Richard D. Palmiter.

Related links

Related links

Related links in Nature Research

Physiology: Microbial signals to the brain control weight

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Palmiter, R. Bone-derived hormone suppresses appetite. Nature 543, 320–321 (2017). https://doi.org/10.1038/nature21501

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature21501

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing