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Cell biology

Killer enzymes tethered

Caspase enzymes promote cell death, but are also involved in sperm development in fruit flies. The discovery that, in sperm, caspase activation is restricted to the surface of organelles called mitochondria sheds light on this unusual role.

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Figure 1: Caspase-mediated sperm development.

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References

  1. Arama, E., Agapite, J. & Steller, H. Dev. Cell 4, 687–697 (2003).

    Article  CAS  Google Scholar 

  2. Aram, L. et al. Dev. Cell 37, 15–33 (2016).

    Article  CAS  Google Scholar 

  3. Fabian, L. & Brill, J. A. Spermatogenesis 2, 197–212 (2012).

    Article  Google Scholar 

  4. Arama, E., Bader, M., Rieckhof, G. E. & Steller, H. PLoS Biol. 5, e251 (2007).

    Article  Google Scholar 

  5. Kaplan, Y., Gibbs-Bar, L., Kalifa, Y., Feinstein-Rotkopf, Y. & Arama, E. Dev. Cell 19, 160–173 (2010).

    Article  CAS  Google Scholar 

  6. Yacobi-Sharon, K., Namdar, Y. & Arama, E. Dev. Cell 25, 29–42 (2013).

    Article  CAS  Google Scholar 

  7. Monaghan, R. M. & Whitmarsh, A. J. Trends Biochem. Sci. 40, 728–735 (2015).

    Article  CAS  Google Scholar 

  8. Yogev, O., Naamati, A. & Pines, O. FEBS J. 278, 4230–4242 (2011).

    Article  CAS  Google Scholar 

  9. Mukhopadhyay, D. & Riezman, H. Science 315, 201–205 (2007).

    Article  ADS  CAS  Google Scholar 

  10. Lu, A. & Pfeffer, S. R. Trends Cell Biol. 24, 389–399 (2014).

    Article  CAS  Google Scholar 

  11. Kuranaga, E. & Miura, M. Trends Cell Biol. 17, 135–144 (2007).

    Article  CAS  Google Scholar 

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Correspondence to Shigekazu Nagata.

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Nagata, S. Killer enzymes tethered. Nature 533, 475–476 (2016). https://doi.org/10.1038/nature18439

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