The selective elimination of cells that have adopted an irreversible, senescent state has now been shown to extend the lifespan of mice and to ameliorate some age-related disease processes. See Article p.184
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Hayflick, L. Exp. Cell Res. 37, 614–636 (1965).
Baker, D. J. et al. Nature 530, 184–189 (2016).
Muñoz-Espin, D. & Serrano, M. Nature Rev. Mol. Cell Biol. 15, 482–496 (2014).
Baker, D. J. et al. Nature 479, 232–236 (2011).
van Deursen, J. M. Nature 509, 439–446 (2014).
Zhu, Y. et al. Aging Cell 14, 644–658 (2015).
Chang, J. et al. Nature Med. 22, 78–83 (2016).
Xu, M. et al. Proc. Natl Acad. Sci. USA 112, E6301–E6310 (2015).
Harrison, D. E. et al. Nature 460, 392–395 (2009).
Herranz, N. et al. Nature Cell Biol. 17, 1205–1217 (2015).
Laberge, R. M. et al. Nature Cell Biol. 17, 1049–1061 (2015).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Gil, J., Withers, D. Out with the old. Nature 530, 164–165 (2016). https://doi.org/10.1038/nature16875
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature16875
This article is cited by
-
Killing the old: cell senescence in atherosclerosis
Nature Reviews Cardiology (2017)