Nature 500, 45–50 (2013); doi:10.1038/nature12415

In this Article, we described integrative genomics analyses of Alzheimer’s disease and associated risk factors. However, reanalysis of the data has showed that sample numbers, image panels and data points were inappropriately manipulated and inaccurate in the ELISA and subcellular localization studies presented in Figs 2d, e, 3b, g, h and 4c, as well as in corresponding Supplementary Figs 10–16. We are in the process of repeating these cell-based studies. We remain confident in the transcriptomics and human genetics analyses reported in the Article. However, given these issues, we wish to retract the Article in its entirety. We deeply regret this circumstance and apologize to the community.