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Pathophysiological consequences of VEGF-induced vascular permeability

Nature volume 437, pages 497–504 (2005)Cite this article

Abstract

Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and ischaemic disease has unexpected pathophysiological consequences. By uncoupling endothelial cell–cell junctions VEGF causes vascular permeability and oedema, resulting in extensive injury to ischaemic tissues after stroke or myocardial infarction. In cancer, VEGF-mediated disruption of the vascular barrier may potentiate tumour cell extravasation, leading to widespread metastatic disease. Therefore, by blocking the vascular permeability promoting effects of VEGF it may be feasible to reduce tissue injury after ischaemic disease and minimize the invasive properties of circulating tumour cells.

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Figure 1: Structural determinants of VEGF-induced leak.
Figure 2: VEGF induces vascular leak.
Figure 3: Signalling pathways implicated in VEGF-induced vascular permeability.
Figure 4: VEGF expression after myocardial infarction.

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  1. Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, 92093-0803, USA

    Sara M. Weis & David A. Cheresh

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Correspondence to David A. Cheresh.

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D.A.C. receives consulting fees and owns stock in TargeGen, Inc., which has developed small molecule inhibitors of vascular permeability.

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Weis, S., Cheresh, D. Pathophysiological consequences of VEGF-induced vascular permeability. Nature 437, 497–504 (2005). https://doi.org/10.1038/nature03987

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