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Cell-specific abnormalities of glutamate transporters in schizophrenia: sick astrocytes and compensating relay neurons?

Molecular Psychiatry volume 21, pages 823–830 (2016)Cite this article

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Abstract

Excitatory amino-acid transporters (EAATs) bind and transport glutamate, limiting spillover from synapses due to their dense perisynaptic expression primarily on astroglia. Converging evidence suggests that abnormalities in the astroglial glutamate transporter localization and function may underlie a disease mechanism with pathological glutamate spillover as well as alterations in the kinetics of perisynaptic glutamate buffering and uptake contributing to dysfunction of thalamo-cortical circuits in schizophrenia. We explored this hypothesis by performing cell- and region-level studies of EAAT1 and EAAT2 expression in the mediodorsal nucleus of the thalamus in an elderly cohort of subjects with schizophrenia. We found decreased protein expression for the typically astroglial-localized glutamate transporters in the mediodorsal and ventral tier nuclei. We next used laser-capture microdissection and quantitative polymerase chain reaction to assess cell-level expression of the transporters and their splice variants. In the mediodorsal nucleus, we found lower expression of transporter transcripts in a population of cells enriched for astrocytes, and higher expression of transporter transcripts in a population of cells enriched for relay neurons. We confirmed expression of transporter protein in neurons in schizophrenia using dual-label immunofluorescence. Finally, the pattern of transporter mRNA and protein expression in rodents treated for 9 months with antipsychotic medication suggests that our findings are not due to the effects of antipsychotic treatment. We found a compensatory increase in transporter expression in neurons that might be secondary to a loss of transporter expression in astrocytes. These changes suggest a profound abnormality in astrocyte functions that support, nourish and maintain neuronal fidelity and synaptic activity.

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Acknowledgements

This work was supported by MH53327 (JHM-W), MH88752 (JHM-W), MH094445 (REM), MH074016 (REM) and Doris Duke Clinical Scientist Award (REM). This work was also supported by the Lindsay Brinkmeyer Schizophrenia Research Fund.

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    R E McCullumsmith & S M O’Donovan

  2. Department of Psychiatry and Behavioral Neurobiology, University of Alabama-Birmingham, Birmingham, AL, USA

    J B Drummond, F S Benesh, M Simmons, R Roberts & J H Meador-Woodruff

  3. Department of Psychiatry, Steward St. Elizabeth’s Medical Center, Brighton, MA, USA

    T Lauriat

  4. Departments of Psychiatry and Neuroscience, The Icahn School of Medicine at Mount Sinai, NY, USA

    V Haroutunian

  5. James J. Peters VA Medical Center, Mental Illness Research Education and Clinical Center (MIRECC), Bronx, NY, USA

    V Haroutunian

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  1. R E McCullumsmith
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  2. S M O’Donovan
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Correspondence to R E McCullumsmith.

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McCullumsmith, R., O’Donovan, S., Drummond, J. et al. Cell-specific abnormalities of glutamate transporters in schizophrenia: sick astrocytes and compensating relay neurons?. Mol Psychiatry 21, 823–830 (2016). https://doi.org/10.1038/mp.2015.148

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