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No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samples

Molecular Psychiatry volume 17, pages 239–241 (2012)Cite this article

Ressler et al.1 recently examined the pituitary adenylate cyclase-activating peptide (PACAP) ligand/type 1 receptor (PAC1) pathway in post-traumatic stress disorder (PTSD) in a predominantly African American (AA) sample. Association analyses examining 44 single nucleotide polymorphisms (SNPs) spanning the PACAP (encoded by ADCYAP1) and PAC1 (encoded by ADCYAP1R1) genes further identified rs2267735, a SNP, in a putative estrogen response element (ERE) within the ADCYAP1R1 gene, which predicted PTSD diagnosis and symptoms in females. We sought to replicate the genetic association between rs2267735 and PTSD in two independent samples.

The first sample consisted of women from the Nurses’ Health Study II (NHSII), a population-based prospective cohort of US female nurses predominantly of European descent. The protocol for the NHSII PTSD study has been published.2 We assessed lifetime trauma exposure and PTSD in 2690 women using a clinically validated structured diagnostic telephone interview. rs2267735 was genotyped using a TaqMan assay at the Channing Laboratory of Brigham and Women's Hospital. Statistical analyses were performed using PLINK.3

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Authors and Affiliations

  1. Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA, USA

    S-C Chang & A L Roberts

  2. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA

    P Xie & J Gelernter

  3. VA CT Healthcare Center, West Haven, CT, USA

    P Xie & J Gelernter

  4. Department of Psychiatry, Center for Alcohol and Drug Programs, Medical University of South Carolina, Charleston, SC, USA

    R F Anton

  5. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

    I De Vivo

  6. Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA

    I De Vivo

  7. Departments of Medicine, Neurology, Ophthalmology, Genetics and Genomics, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA

    L A Farrer

  8. Department of Psychiatry, University of Pennsylvania and the Philadelphia VA Medical Center, Philadelphia, PA, USA

    H R Kranzler & D Oslin

  9. Department of Psychiatry, Psychiatric and Neurodevelopment Genetics Unit, Center for Genetic Research Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    S M Purcell & J W Smoller

  10. The Broad Institute, Cambridge, MA, USA

    S M Purcell

  11. Center for Molecular Medicine and Genetics and Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA

    M Uddin

  12. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

    J Gelernter

  13. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

    K C Koenen

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  1. S-C Chang
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  2. P Xie
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  3. R F Anton
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  4. I De Vivo
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  5. L A Farrer
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  6. H R Kranzler
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  7. D Oslin
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  8. S M Purcell
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  9. A L Roberts
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  10. J W Smoller
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  11. M Uddin
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  12. J Gelernter
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  13. K C Koenen
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Corresponding authors

Correspondence to J Gelernter or K C Koenen.

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Chang, SC., Xie, P., Anton, R. et al. No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samples. Mol Psychiatry 17, 239–241 (2012). https://doi.org/10.1038/mp.2011.118

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  • DOI: https://doi.org/10.1038/mp.2011.118

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