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A study of rare structural variants in schizophrenia patients and normal controls from Chinese Han population

Molecular Psychiatry volume 13, pages 911–913 (2008)Cite this article

Schizophrenia (MIM 181500) is a severe and common psychiatric disorder affecting ∼1% of the world population. As a leading cause of psychiatric admissions, schizophrenia accounts for a considerable portion of health-care expenditures and is viewed as a major public health concern.1 Due to the complexity of schizophrenia, its genetic etiology is still unclear.2

Structural variation or copy number variation (CNV) is widely distributed in human genome and accounts for more genomic differences than single nucleotide polymorphisms.3, 4 Genomic rearrangements and gene copy-number alterations have already been considered as causes of nervous system disorders.5 Recently, Walsh et al.6 found that schizophrenia patients, especially young onset schizophrenia patients, carried extremely more gene-based microdeletions or microduplications (larger than 100 kb) than normal controls, and implicated a ‘common disease-rare variant’ assumption. To validate their finding, we carried out a genome-wide replication study of rare CNVs in Chinese Han sample set.

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Acknowledgements

We sincerely thank all the participants for their participation in this study and all the medical staff involved in sample collection and diagnosis. This work was supported by grants from 863 program (NO.2006AA02A407) of China, and the Shanghai Leading Academic Discipline Project (B205).

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Authors and Affiliations

  1. Bio-X Center, Shanghai Jiao Tong University, Shanghai, PR China

    Y Y Shi, G He, Z Zhang, W Tang, J Zhang Jr, Q Zhao, J Zhang Sr, X W Li, Z R Xi, C Fang, X Z Zhao & L He

  2. Changning Institute of Mental Health, The Bio-X Center Hospital, Shanghai, PR China

    Y Y Shi & L He

  3. Shanghai Institute of Mental Health, Shanghai, PR China

    G Y Feng

  4. Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China

    L He

  5. Institutes of Biomedical Sciences, Fudan University (IBS), Shanghai, PR China

    X Z Zhao & L He

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  1. Y Y Shi
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  2. G He
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  13. L He
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Correspondence to Y Y Shi, G He or L He.

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Shi, Y., He, G., Zhang, Z. et al. A study of rare structural variants in schizophrenia patients and normal controls from Chinese Han population. Mol Psychiatry 13, 911–913 (2008). https://doi.org/10.1038/mp.2008.69

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