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Normal and leukemic stem cells

Leukemia Supplements volume 1, pages S54–S55 (2012)Cite this article

Abstract

Studies on hematopoietic stem cells have provided several critical insights in the biology of stem cells in general; as mature blood cells are generally short lived, stem cells are in fact required to guarantee, throughout the life of an organism, the replenishment of differentiated blood cells by the generation of multi-lineage progenitors and precursors committed to individual hematopoietic lineages. Similarly, acute myeloid leukemia has been considered as a model system to study cancer stem cells. This presentation illustrates some recent results obtained by our group with regard to both normal and leukemic stem cells.

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References

  1. Viale A, De Franco F, Orleth A, Cambiaghi V, Giuliani V, Bossi D et al. Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. Nature 2009; 457: 51–56.

    Article  CAS  Google Scholar 

  2. Cicalese A, Bonizzi G, Pasi CE, Faretta M, Ronzoni S, Giulini B et al. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 2009; 138: 1083–1095.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

    P G Pelicci

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  1. P G Pelicci
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Correspondence to P G Pelicci.

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The author declares no conflict of interest.

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This article was published as part of a supplement that was supported by Novartis, MSD Italia, Roche, Celgene, GlaxoSmithKline, Sanofi, Gilead, Adienne, Italfarmaco, Pierre Fabre Pharmaceuticals with an unrestricted educational contribution to AREO – Associazione Ricerche Emato-Oncologiche (Genoa) and AMS – Associazione Malattie del Sangue (Milan) for the purpose of advancing research in acute and chronic leukemia.

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Pelicci, P. Normal and leukemic stem cells. Leukemia Suppl 1 (Suppl 2), S54–S55 (2012). https://doi.org/10.1038/leusup.2012.27

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  • DOI: https://doi.org/10.1038/leusup.2012.27

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