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No evidence for microsatellite instability in acute myeloid leukemia

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References

  1. Hause RJ, Pritchard CC, Shendure J, Salipante SJ . Classification and characterization of microsatellite instability across 18 cancer types. Nat Med 2016; 22: 1342–1350.

    Article  CAS  Google Scholar 

  2. de la Chapelle A, Hampel H . Clinical relevance of microsatellite instability in colorectal cancer. J Clin Oncol 2010; 28: 3380–3387.

    Article  CAS  Google Scholar 

  3. McMeekin DS, Tritchler DL, Cohn DE, Mutch DG, Lankes HA, Geller MA et al. Clinicopathologic significance of mismatch repair defects in endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study. J Clin Oncol 2016; 34: 3062–3068.

    Article  CAS  Google Scholar 

  4. Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 2015; 372: 2509–2520.

    Article  CAS  Google Scholar 

  5. Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW . Cancer genome landscapes. Science 2013; 339: 1546–1558.

    Article  CAS  Google Scholar 

  6. Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med 2016; 374: 2209–2221.

    Article  CAS  Google Scholar 

  7. Das-Gupta EP, Seedhouse CH, Russell NH . Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia. Br J Haematol 2001; 114: 307–312.

    Article  CAS  Google Scholar 

  8. Rimsza LM, Kopecky KJ, Ruschulte J, Chen IM, Slovak ML, Karanes C et al. Microsatellite instability is not a defining genetic feature of acute myeloid leukemogenesis in adults: results of a retrospective study of 132 patients and review of the literature. Leukemia 2000; 14: 1044–1051.

    Article  CAS  Google Scholar 

  9. Nomdedéu JF, Perea G, Estivill C, Lasa A, Carnicer MJ, Brunet S et al. Microsatellite instability is not an uncommon finding in adult de novo acute myeloid leukemia. Ann Hematol 2005; 84: 368–375.

    Article  Google Scholar 

  10. Salipante SJ, Scroggins SM, Hampel HL, Turner EH, Pritchard CC . Microsatellite instability detection by next generation sequencing. Clin Chem 2014; 60: 1192–1199.

    Article  CAS  Google Scholar 

  11. Eisfeld A-K, Mrózek K, Kohlschmidt J, Nicolet D, Orwick S, Walker CJ et al. The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia. Leukemia 2017; e-pub ahead of print 21 March 2017; doi: 10.1038/leu.2017.86.

  12. Walker CJ, Miranda MA, O'Hern MJ, Blachly JS, Moyer CL, Ivanovich J et al. MonoSeq variant caller reveals novel mononucleotide run indel mutations in tumors with defective DNA mismatch repair. Hum Mutat 2016; 37: 1004–1012.

    Article  CAS  Google Scholar 

  13. Kim TM, Laird PW, Park PJ . The landscape of microsatellite instability in colorectal and endometrial cancer genomes. Cell 2013; 155: 858–868.

    Article  CAS  Google Scholar 

  14. Herzog G, Lu-Hesselmann J, Zimmermann Y, Haferlach T, Hiddemann W, Dreyling M . Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events. Haematologica 2005; 90: 693–695.

    CAS  PubMed  Google Scholar 

  15. Sheikhha MH, Tobal K, Liu Yin JA . High level of microsatellite instability but not hypermethylation of mismatch repair genes in therapy-related and secondary acute myeloid leukaemia and myelodysplastic syndrome. Br J Haematol 2002; 117: 359–365.

    Article  CAS  Google Scholar 

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Acknowledgements

We acknowledge: the patients who consented to provide material for this study; Donna Bucci and Wacharaphon Vongchucherd of The Alliance NCTN Biorepository and Biospecimen Resource for sample processing and storage services; and Lisa J. Sterling of The Ohio State University Comprehensive Cancer Center for data management. This work was supported by National Institutes of Health National Cancer Institute grants CA180821 and CA180882 (to the Alliance for Clinical Trials in Oncology), CA196171, CA077658, CA180850, CA180861, CA140158, CA016058, and the Leukemia Clinical Research Foundation. The content is solely the responsibility of the authors and does not represent the official views of the National Institutes of Health.

Author contributions

CJW, A-KE, RB, AdlC and CDB contributed to the study design and to the data interpretation; CJW, A-KE, RB, KM, AdlC and CDB wrote the manuscript; CJW, A-KE, LKG and MB performed laboratory-based research; JK performed statistical analysis; AJC, KM, JEK, BLP, ESW, RMS and CDB were involved directly or indirectly in the care of patients and/or sample procurement. All authors read and agreed on the final version of the manuscript.

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Correspondence to C J Walker.

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Walker, C., Eisfeld, AK., Genutis, L. et al. No evidence for microsatellite instability in acute myeloid leukemia. Leukemia 31, 1474–1476 (2017). https://doi.org/10.1038/leu.2017.97

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