This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation
Nature Communications Open Access 07 June 2022
-
Identification of genes and pathways potentially related to PHF20 by gene expression profile analysis of glioblastoma U87 cell line
Cancer Cell International Open Access 04 October 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Malumbres M, Barbacid M . RAS oncogenes: the first 30 years. Nat Rev Cancer 2003; 3: 459–465.
Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D . RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer 2011; 11: 761–774.
Ward AF, Braun BS, Shannon KM . Targeting oncogenic Ras signaling in hematologic malignancies. Blood 2012; 120: 3397–3406.
Kong G, Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J et al. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. J Clin Invest 2014; 124: 2762–2773.
Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS et al. Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov 2014; 4: 1418–1429.
Wang JY, Liu YG, Li ZY, Du J, Ryu MJ, Taylor PR et al. Endogenous oncogenic Nras mutation leads to aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood 2010; 116: 5991–6002.
Wang JY, Liu YG, Li ZY, Wang ZD, Tan LX, Ryu MJ et al. Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood 2011; 118: 368–379.
Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K et al. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood 2011; 117: 2022–2032.
Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E et al. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discov 2013; 3: 993–1001.
Kong G, Chang Y-I, Damnernsawad A, You X, Du J, Ranheim RA et al. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis. Leukemia 2016; 30: 1542–1551.
Wang J, Kong G, Liu Y, Du J, Chang Y-I, Zhang X et al. Nras G12D/+ promotes leukemogenesis by aberrantly regulating haematopoietic stem cell functions. Blood 2013; 121: 5203–5207.
Acknowledgements
We thank the University of Wisconsin Carbone Comprehensive Cancer Center (UWCCC) for use of its Shared Services (Flow Cytometry Laboratory and Experimental Pathology Laboratory) to complete this research. This work was supported by R01 grants R01CA152108 and R01HL113066, and a Scholar Award from the Leukemia and Lymphoma Society to JZ. This work was also supported in part by National Institutes of Health/National Cancer Institute P30 CA014520-UWCCC support.
Author contributions
GK and JZ contributed for experimental design, execution as well as writing of this manuscript; Y-IC, XY and YZ for experimental execution; EAR for histopathological analysis and writing of this manuscript; and CEB for generating NrasLSL Q61R/+ allele and writing of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies this paper on the Leukemia website
Supplementary information
Rights and permissions
About this article
Cite this article
Kong, G., Chang, YI., You, X. et al. The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent. Leukemia 30, 1935–1938 (2016). https://doi.org/10.1038/leu.2016.89
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2016.89
This article is cited by
-
Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation
Nature Communications (2022)
-
Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice
Leukemia (2022)
-
A model for RAS mutation patterns in cancers: finding the sweet spot
Nature Reviews Cancer (2018)
-
Identification of genes and pathways potentially related to PHF20 by gene expression profile analysis of glioblastoma U87 cell line
Cancer Cell International (2017)