Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children’s Oncology Group Study

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Winter SS . Pediatric acute leukemia therapies informed by molecular analysis of high-risk disease. Hematology Am Soc Hematol Educ Program 2011; 2011: 366–373.

    Article  Google Scholar 

  2. Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ et al. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group. J Clin Oncol 2012; 30: 1663–1669.

    Article  Google Scholar 

  3. Schrappe M, Valsecchi MG, Bartram CR, Schrauder A, Panzer-Grümayer R, Möricke A et al. Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study. Blood 2011; 118: 2077–2084.

    Article  CAS  Google Scholar 

  4. Asselin BL, Devidas M, Wang C, Pullen J, Borowitz MJ, Hutchison R et al. Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404). Blood 2011; 118: 874–883.

    Article  CAS  Google Scholar 

  5. Van Vlierberghe P, Ferrando A . The molecular basis of T cell acute lymphoblastic leukemia. J Clin Invest 2012; 122: 3398–3406.

    Article  CAS  Google Scholar 

  6. Soulier J, Clappier E, Cayuela JM, Regnault A, García-Peydró M, Dombret H et al. HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). Blood 2005; 106: 274–286.

    Article  CAS  Google Scholar 

  7. Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 2003; 102: 262–268.

    Article  CAS  Google Scholar 

  8. Brandimarte L, Pierini V, Di Giacomo D, Borga C, Nozza F, Gorello P et al. New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia. Blood 2013; 121: 5064–5067.

    Article  CAS  Google Scholar 

  9. Romana SP, Radford-Weiss I, Ben Abdelali R, Schluth C, Petit A, Dastugue N et al. NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogenetique Hematologique. Leukemia 2006; 20: 696–706.

    Article  CAS  Google Scholar 

  10. Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D et al. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol 2009; 10: 147–156.

    Article  CAS  Google Scholar 

  11. Ben Abdelali R, Asnafi V, Petit A, Micol JB, Callens C, Villarese P et al. The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest. Haematologica 2013; 98: 1711–1717.

    Article  Google Scholar 

  12. Patrick K, Wade R, Goulden N, Mitchell C, Moorman AV, Rowntree C et al. Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003. Br J Haematol 2014; 166: 421–424.

    Article  CAS  Google Scholar 

  13. Wood BL, Winter SS, Dunsmore KP, Devidas M, Chen S, Asselin B et al. T-Lymphoblastic Leukemia (T-ALL) Shows Excellent Outcome, Lack of Significance of the Early Thymic Precursor (ETP) Immunophenotype, and Validation of the Prognostic Value of the End-Induction Minimal Residual Disease (MRD) in Children’s Oncology Group (COG) Study AALL0434. Blood 2014; 124: 21.

    Article  Google Scholar 

  14. Balgobind BV, Raimondi SC, Harbott J, Zimmermann M, Alonzo TA, Auvrignon A et al. Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study. Blood 2009; 114: 2489–2496.

    Article  CAS  Google Scholar 

  15. Lo Nigro L, Mirabile E, Tumino M, Caserta C, Cazzaniga G, Rizzari C et al. Detection of PICALM-MLLT10 (CALM-AF10) and outcome in children with T-lineage acute lymphoblastic leukemia. Leukemia 2013; 27: 2419–2421.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We acknowledge the Mayo Clinic Cytogenetics Core Facility (Patricia T. Greipp, DO, Darlene Knutson, Sara Nelson) and the UNM Analytical and Translational Genomics Shared Resources (Jamie L Padilla, Jennifer Woods, Maggie Cyphery, Jason Byars and Gavin Pickett, PhD) at UNM Cancer Center. We thank the COG Cell Bank for the provision of patient samples and annotated demographic data. We express our deep gratitude and greatest praise to the patients and parents who participated in COG Cell Bank, Biology and Therapeutic studies in hopes of helping others. We apologize to all authors whose work could not be cited due to space constraints. Grant support: NIH R01 CA114589 (SSW). NIH 1U54 TR134901 (RSL). NIH NCATS 8UL1TR000041 and Dedicated Health Research Funds from the University of New Mexico School of Medicine (KM-W). P30 CA118100 Keck-UNM Genomic Shared Resource, NIH R01 CA170250 (SAN). Intramural Research Program of the NIH, NCI (PDA, MO). U10 CA98543 (COG Chair's grant), U10 CA98413 (COG Statistics and Data Center grant), and U24 CA114766 (Specimen Banking), U10 CA180886 (COG Operations Center), U10 CA180899 (COG Statistics and Data Center).

Author contributions

Conception and design; KMW and SSW. Administrative support; MD, MLL, SPH, BLA and KPD. Provision of study materials or patients; MLL. Collection and assembly of data; KMW, HK, JW, RCH, CKN, SAN, MR, YL, MO, CM, IMC and KGR. Data analysis and interpretation; KMW, HK, MD, JW, RCH, BLW, BLA, AB, JS, HD, JZ, RSL, EAR, WLC, NJW, PDA, MLL, CGM, SPH, NAH, AJC, KPD and SSW. Manuscript writing and final approval of manuscript; all authors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K Matlawska-Wasowska.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies this paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Matlawska-Wasowska, K., Kang, H., Devidas, M. et al. MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children’s Oncology Group Study. Leukemia 30, 1909–1912 (2016). https://doi.org/10.1038/leu.2016.60

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2016.60

This article is cited by

Search

Quick links