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How to Manage…

How to manage mantle cell lymphoma

Leukemia volume 28, pages 2117–2130 (2014)Cite this article

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Abstract

Mantle cell lymphoma (MCL) is no longer a hopeless disease. Considered to carry a uniformly dismal prognosis so far, during the last years it has been rediscovered as a heterogeneous clinical and biological entity. Such a complexity has been highlighted by molecular genetics, unraveling different pathways of cell survival and progression. Concurrently, the application of new therapeutic paradigms including rituximab, high-dose cytarabine and stem cell transplantation dramatically improved treatment activity and the introduction of innovative targeted molecules has already led to new patient perspectives. In this completely new and continually evolving landscape, the clinical hemato-oncologist might feel disoriented on what are the best current strategies to handle such a critical disease and the gold standard therapeutic options for MCL. Here we address some burning questions on how to manage MCL patients, spacing from prognostic issues to the dilemma of personalized treatment in different scenarios of the disease: how to diagnose an MCL? Which are the fundamental staging procedures? What are the most reliable prognosticators? Is there a place for watch and wait? Which are the best treatment options for younger, elderly and frail patients? Which patients are addressable to high-dose therapy? What is the role of allogeneic transplantation? What is the most appropriate approach for relapsing disease in different categories of patients? What novelties are going to be introduced in the near future? The practical algorithms here discussed represent an evidence-based approach derived from results of multicenter and randomized trials.

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  1. M Dreyling and S Ferrero: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine III, University Hospital Großhadern/LMU München, Medizinische Klinik und Poliklinik III, Klinikum der Universität, München, Germany

    M Dreyling

  2. Division of Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino, Italy

    S Ferrero

  3. Department of Adult Hematology, Necker Hospital, Assistance Publique, Paris, France

    O Hermine

  4. Imagine Institute, Sorbonne Paris Cité University, Paris, France

    O Hermine

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  1. M Dreyling
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  3. O Hermine
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M Dreyling reports financial support of clinical studies (Celgene, Janssen, Mundipharma, Pfizer, Roche), scientific advisory boards (Bayer, Celgene, Janssen, Pfizer) and speaker’s honoraria (Celgene, Janssen, Mundipharma, Pfizer, Roche).

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Dreyling, M., Ferrero, S. & Hermine, O. How to manage mantle cell lymphoma. Leukemia 28, 2117–2130 (2014). https://doi.org/10.1038/leu.2014.171

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