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A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia

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Acknowledgements

We would like to thank Dr Geraldine Anne Boyd for her help. This work was supported by ‘Associazione Umbra Leucemie e Linfomi’, Perugia Italy, by ‘Associazione Italiana Leucemie, Linfomi e Mieloma’, L’Aquila Section, L’Aquila, Italy and by grant from Progetti di Ricerca di Interesse Nazionale-PRIN (2010-2011—prot. 2010MCLPLB_005; to ER). LR is a Leukemia and Lymphoma Society Scholar in Clinical Research.

Author contributions

PS analyzed and interpreted the data, conducted the statistical analyses and wrote the manuscript; SB developed the AR-PCR assay, performed the experimental work and contributed in writing the manuscript; BDP conducted part of the statistical analyses and contributed in writing the manuscript; PA and ED performed the molecular diagnostic assays; LR conducted part of the statistical analyses; SP, VA and ADT contributed patient samples and data; ER and PM contributed to interpretation of biological data; MDI and FF led the project, supervised the study and wrote the manuscript. All authors critically reviewed the final manuscript.

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Correspondence to P Sportoletti.

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Sportoletti, P., Baldoni, S., Del Papa, B. et al. A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia. Leukemia 28, 436–439 (2014). https://doi.org/10.1038/leu.2013.289

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