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Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and multiple myeloma risk: a case–control study in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium

Leukemia volume 26, pages 1419–1422 (2012)Cite this article

A Corrigendum to this article was published on 10 July 2013

Multiple myeloma (MM) is a hematological neoplasm that arises from a single clone of malignant plasma cells in the bone marrow. In Europe, 4.6/100 000 males and 3.2/100 000 females every year develop MM, with a median age at diagnosis around 60 years.1

The observation of a higher risk to develop MM among first-degree relatives of MM patients in several population-based case–control studies supports the idea that genetic factors are involved in MM pathogenesis.2 Therefore, several studies focusing on various genes and pathways have tried to identify single-nucleotide polymorphisms (SNPs) associated with the susceptibility to the disease.3, 4

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Acknowledgements

We acknowledge support by the recruiting hospitals and physicians of the study regions as well as their collaborating nurses and technicians. We thank Dr Fabienne Lesueur (IARC, Lyon, France) for the collection on French controls and Dr Victor Moreno (IDBELL, Barcelona, Spain) for the recruitment of Spanish controls. We thank Prof. Bugert at the Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service Baden-Württemberg-Hessen for providing German control DNA samples. This work was partially supported by the grants P08-CVI-4116 from the Consejería de Salud de la Junta de Andalucia (Sevilla, Spain), PI081051 from the Fondo de Investigaciones Sanitarias (Madrid, Spain) and NN402178334 from the Polish Ministry of Science and Higher Education (Lodz, Poland).

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Authors and Affiliations

  1. Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany

    A Martino, D Campa, A Stein & F Canzian

  2. Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa University, Pisa, Italy

    G Buda, E Orciuolo & M Petrini

  3. Genomic Oncology Area, Genyo - Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research, Granada, Spain

    J Sainz, M Jurado & R Ríos

  4. Department of Hematology, Virgen de las Nieves University Hospital, Granada, Spain

    J Sainz, M Jurado & R Ríos

  5. Hematology Division, University Hospital of Salamanca, Universidad de Salamanca-Consejo Superior de Investigaciones Científicas, Salamanca, Spain

    R García-Sanz

  6. Department of Hematology, Medical University of Lodz, Lodz, Poland

    K Jamroziak & Z Szemraj-Rogucka

  7. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal

    R M Reis & H Marques

  8. Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil

    R M Reis

  9. Department of Internal Medicine, Medizinische Klinik V, Universitaetsklinikum Heidelberg, Heidelberg, Germany

    N Weinhold & H Goldschmidt

  10. Department of Medical Biochemistry, Medical University of Lodz, Lodz, Poland

    J Szemraj

  11. Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany

    R Kumar

  12. Department of Biology, Section of Genetics, University of Pisa, Pisa, Italy

    F Gemignani, S Landi & A M Rossi

  13. INSERM U590, Laboratoire de Cytologie Analytique, Faculte de Medecine Rockefeller, Universite Claude Bernard Lyon I, Lyon, France

    C Dumontet

Authors
  1. A Martino
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  22. F Canzian
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Corresponding author

Correspondence to A Martino.

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Martino, A., Campa, D., Buda, G. et al. Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and multiple myeloma risk: a case–control study in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium. Leukemia 26, 1419–1422 (2012). https://doi.org/10.1038/leu.2011.352

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