Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

High rate of TNFRSF14 gene alterations related to 1p36 region in de novo follicular lymphoma and impact on prognosis

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Cheung KJ, Delaney A, Ben-Neriah S, Schein J, Lee T, Shah SP et al. High resolution analysis of follicular lymphoma genomes reveals somatic recurrent sites of copy-neutral loss of heterozygosity and copy number alterations that target single genes. Genes Chromosomes Cancer 2010; 49: 669–681.

    Article  CAS  PubMed  Google Scholar 

  2. Cheung KJ, Shah SP, Steidl C, Johnson N, Relander T, Telenius A et al. Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances. Blood 2009; 113: 137–148.

    Article  CAS  PubMed  Google Scholar 

  3. Schwaenen C, Viardot A, Berger H, Barth TF, Bentink S, Dohner H et al. Microarray-based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status. Genes Chromosomes Cancer 2009; 48: 39–54.

    Article  CAS  PubMed  Google Scholar 

  4. Costello RT, Mallet F, Barbarat B, Schiano De Colella JM, Sainty D, Sweet RW et al. Stimulation of non-Hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity. Leukemia 2003; 17: 2500–2507.

    Article  CAS  PubMed  Google Scholar 

  5. Harrop JA, McDonnell PC, Brigham-Burke M, Lyn SD, Minton J, Tan KB et al. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. J Biol Chem 1998; 273: 27548–27556.

    Article  CAS  PubMed  Google Scholar 

  6. Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 2011; 476: 298–303.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Compaan DM, Gonzalez LC, Tom I, Loyet KM, Eaton D, Hymowitz SG . Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex. J Biol Chem 2005; 280: 39553–39561.

    Article  CAS  PubMed  Google Scholar 

  8. Cheung KJ, Johnson NA, Affleck JG, Severson T, Steidl C, Ben-Neriah S et al. Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis. Cancer Res 2010; 70: 9166–9174.

    Article  CAS  PubMed  Google Scholar 

  9. M’Hidi H, Thibult ML, Chetaille B, Rey F, Bouadallah R, Nicollas R et al. High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Am J Clin Pathol 2009; 132: 589–596.

    Article  PubMed  Google Scholar 

  10. Pangault C, Ame-Thomas P, Ruminy P, Rossille D, Caron G, Baia M et al. Follicular lymphoma cell niche: identification of a preeminent IL-4-dependent T(FH)-B cell axis. Leukemia 2010; 24: 2080–2089.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This study was supported by research fundings from the Institut National du Cancer (INCa libre 2005-PL070). We thank the ‘Centre de Ressources (CRB)-Santé’ of Rennes’ Hospital, Jean-Michel Picquenot and Patrick Tas for providing follicular lymphoma lymph nodes; Vinciane Rainville, Elodie Bohers and Françoise Parmentier for their technical assistance.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T Fest.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies the paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Launay, E., Pangault, C., Bertrand, P. et al. High rate of TNFRSF14 gene alterations related to 1p36 region in de novo follicular lymphoma and impact on prognosis. Leukemia 26, 559–562 (2012). https://doi.org/10.1038/leu.2011.266

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2011.266

This article is cited by

Search

Quick links