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A novel ABL1 fusion to the SH2 containing inositol phosphatase-1 (SHIP1) in acute lymphoblastic leukemia (ALL)

Leukemia volume 25, pages 1645–1649 (2011)Cite this article

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The BCR/ABL fusion gene is the most common fusion in leukemia. The BCR/ABL fusion is the hallmark of chronic myeloid leukemia and is found in about 20% of all B-lineage acute lymphoblastic leukemias (ALL). The BCR/ABL fusion leads to the constitutive activation of the ABL1 tyrosine kinase via the oligomerization of the fusion protein mediated by the coiled-coiled domain of BCR.1, 2

Even though the ABL tyrosine kinase is one of the most frequently activated kinases in hematological malignancy, other than BCR,3 only six additional ABL1 fusion partners have been identified: ETV6,4 RCSD1,5 EML1,6 NUP214,7 ZMIZ18 and SFPQ.9 Except for NUP214, the other ABL1 fusions are rare. For RCSD1, EML1, ZMIZ1 and SFPQ, only case reports have been described.10 Only the NUP214/ABL1 fusion is found recurrently in approximately 6% of the T-ALL cases.7 Here, we describe the discovery and characterization of the novel ABL1 fusion to the SH2-containing inositol phosphatase-1 (SHIP1; INPP5D).

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Acknowledgements

SKB is supported by a grant from the Deutsche Forschungsgemeinschaft DFG (SFB 684, A6), a grant from the German Ministry of Education and Research (BMBF) National genome research network (NGFNplus) (PKL-01GS0876-6) and by institutional funding from the Helmholtz Zentrum Munich, German Research Center for Environmental Health.

Author Contributions

PMK designed and performed experiments and wrote the manuscript. BT and GM performed experiments. KS contributed reagents and proof-read the article. SKB designed and performed experiments, supervised the project and wrote the manuscript.

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Authors and Affiliations

  1. Department of Medicine III, Laboratory of Leukemia Diagnostics, University of Munich Hospital, Munich, Germany

    P M Kakadia, G Mellert, K Spiekermann & S K Bohlander

  2. Helmholtz Zentrum Munich, National Research Center for Environmental Health, Clinical Cooperative Group ‘Leukemia’, Munich, Germany

    P M Kakadia, B Tizazu, K Spiekermann & S K Bohlander

  3. Oncogenetic Laboratory - Department of Pediatric Hematology/Oncology, Justus Liebig-University, Giessen, Germany

    J Harbott & S Röttgers

  4. DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany

    H Quentmeier

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  1. P M Kakadia
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Correspondence to S K Bohlander.

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Kakadia, P., Tizazu, B., Mellert, G. et al. A novel ABL1 fusion to the SH2 containing inositol phosphatase-1 (SHIP1) in acute lymphoblastic leukemia (ALL). Leukemia 25, 1645–1649 (2011). https://doi.org/10.1038/leu.2011.129

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