This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Somatostatin receptor mediated targeting of acute myeloid leukemia by photodynamic metal complexes for light induced apoptosis
Scientific Reports Open Access 15 January 2020
-
Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence
Cell Death & Disease Open Access 16 August 2012
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Kroemer G, Jaattela M . Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005; 5: 886–897.
Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U et al. Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem 2008; 283: 19140–19150.
Boya P, Andreau K, Poncet D, Zamzami N, Perfettini JL, Metivier D et al. Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med 2003; 197: 1323–1334.
Puissant A, Colosetti P, Robert G, Cassuto JP, Raynaud S, Auberger P . Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR-ABL cleavage and elimination of chronic myelogenous leukemia cells. Leukemia 2010; 24: 115–124.
Jacquel A, Colosetti P, Grosso S, Belhacene N, Puissant A, Marchetti S et al. Apoptosis and erythroid differentiation triggered by Bcr-Abl inhibitors in CML cell lines are fully distinguishable processes that exhibit different sensitivity to caspase inhibition. Oncogene 2007; 26: 2445–2458.
Thiele DL, Lipsky PE . Apoptosis is induced in cells with cytolytic potential by L-leucyl-L-leucine methyl ester. J Immunol 1992; 148: 3950–3957.
Erdal H, Berndtsson M, Castro J, Brunk U, Shoshan MC, Linder S . Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proc Natl Acad Sci USA 2005; 102: 192–197.
Ivanov A, Beers SA, Walshe CA, Honeychurch J, Alduaij W, Cox KL et al. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J Clin Invest 2009; 119: 2143–2159.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies the paper on the Leukemia website ()
Supplementary information
Rights and permissions
About this article
Cite this article
Puissant, A., Dufies, M., Raynaud, S. et al. Targeting lysosomes to eradicate imatinib-resistant chronic myelogenous leukemia cells. Leukemia 24, 1099–1101 (2010). https://doi.org/10.1038/leu.2010.55
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2010.55
This article is cited by
-
Somatostatin receptor mediated targeting of acute myeloid leukemia by photodynamic metal complexes for light induced apoptosis
Scientific Reports (2020)
-
Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence
Cell Death & Disease (2012)